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Chemists Stay a Step Ahead of Drug Testers
Internet Offers New Steroids Designed to Be Undetectable
If members of Congress leading efforts to eradicate performance-enhancing drugs from athletics want to get an idea of just how difficult that will be, they need only turn to the Internet.
While the Bay Area Laboratory Co-Operative investigation continues in San Francisco and Major League Baseball officials argue with the players' union over what penalties should be handed down to drug offenders, the Web already offers a new generation of steroids designed to avoid current tests.
The Washington Post obtained five dietary supplements -- each of which touted its ability to build muscle fast -- available online and asked a prominent Los Angeles researcher to test them. Don Catlin, who directs the U.S. Olympic drug testing lab at UCLA, said four of the products contained previously undetected anabolic steroids. One contained a steroid that came to the attention of authorities just two years ago but, until now, was thought to be in only limited circulation.
"They are all steroids," Catlin said in a telephone interview after running tests on the substances, which are available in pill or liquid form. "They are all going to be effective." The Post reimbursed Catlin for the cost of testing the substances.
It is impossible to gauge the use of these so-called designer steroids. But their discovery shows how professional athletes, including Major League Baseball and National Football League players and Olympic athletes subject to regular, mandatory drug tests, continue to have at their disposal performance-enhancing products that are not detectable.
Catlin said the steroids are reminiscent of tetrahydrogestrinone, or THG, and norbolethone, the two steroids connected to BALCO, the Burlingame, Calif.-based nutritional supplements company whose clients included Barry Bonds of the San Francisco Giants and more than a dozen professional baseball and football players and track and field athletes. But unlike THG, which was sold secretly to elite athletes before Catlin discovered it in 2003, the five supplements obtained by The Post are widely available -- and affordable. Their costs ranged from $50 to $125 per bottle.
And this might just be the beginning. Two officials with prominent U.S. dietary supplement companies, who spoke on condition of anonymity, said it is easy for companies to outwit drug testers. "There's an unlimited pool of steroids," one official said. "You could do this for the next 100 years. . . . The longer they don't pay attention the [more rampant] it gets."
Difficult Market to Stop
Despite all the attention being given to steroid use in sports, chemists have apparently been able to manufacture a steady stream of new steroids, often by just slightly altering the chemical properties of known banned drugs or by turning to long-forgotten recipes from steroid cookbooks from the 1950s and 1960s. "It's pretty obvious what's going on," Catlin said. The companies "are making tons of money. If they don't get caught, they turn on the spigot and turn out more."
"It's not very difficult for some smart chemist to bypass" the law, said Olivier Rabin, the science director at the World Anti-Doping Agency, which sets drug policy for many international sports. The Montreal-based agency announced last month that it would place the steroids in three of the products obtained by The Post on its 2006 list of banned drugs following an internal review that was not connected to Catlin's analysis.
The supplement company officials said the lenient sentences handed down in the BALCO probe seem to have emboldened U.S. companies to delve into the distribution of newly created designer steroids, moving an industry previously the secret domain of black-market chemists, tight-lipped middlemen and small groups of elite athletes into the mainstream.
BALCO founder Victor Conte, who admitted giving steroids and other drugs to athletes, negotiated a plea deal with federal prosecutors this year that included just four months imprisonment. Former NFL linebacker Bill Romanowski admits in a new book that he used Conte's designer steroids to avoid the league's drug testing program. "As soon as I found out something could be tested for, I stopped taking it," the book states, CBS News reported Sunday.
In response to the furor over the BALCO revelations, Congress this year held several high-profile hearings in which it heard testimony from athletes and sports league commissioners about steroid use. Lawmakers introduced four separate bills aimed at imposing federal drug-testing standing standards on professional sports, though none is expected to pass this year.
Officials within the dietary supplement industry said increasingly rigorous drug testing in U.S. professional sports and tougher anti-steroid laws -- the Anabolic Steroid Act of 2004 made 36 steroids illegal, bringing the total to 59 banned in the United States -- have sent the demand for undetectable steroids skyrocketing.
Catlin said that in more than 20 years in Olympic drug testing, he had found only three designer steroids, all between 2002 and 2004, before this summer, when The Post sent him the five dietary supplements. "THG was the thing that broke it all open," Catlin said. "It's a simple step to expect that more people will come into the market because there's money to be made."
Athletes have for decades sought out anabolic steroids because they help build muscle and endurance. But steroids are also known for undesirable side effects and most professional sports have banned their use.
The five products tested by Catlin were: Superdrol [= methylmasteron - red.], supplied by Designer Supplements of New Hyde Park, N.Y., for Anabolic Xtreme of San Diego; Prostanozol [= winstrol zonder methylgroep - red] and Ergomax LMG, both marketed by Applied Lifescience Research Industries (ALRI) of Las Vegas; Methyl 1-P, sold by Legal Gear of Brighton, Mich.; and, FiniGenX Magnum Liquid, sold by PharmaGenX of San Marcos, Calif. Representatives from each of the companies declined or did not respond to multiple written and telephone requests for interviews.
Kevin Smith, the president of Anabolic Xtreme, said in an e-mail that the company no longer distributes Superdrol.
ALRI head Author L. Rea and industry partner Bruce Kneller of Gaspari Nutrition, which has a working relationship with ALRI, wrote in an open letter to The Post on a public Internet message board that "none of the compounds we have developed and currently market are in current violation of any controlled substance act at either the federal or state level. . . . We feel our products are correctly [and legally] marketed to and for educated, intelligent adult men."
Known steroids were first banned in the United States in the Anabolic Steroid Control Act of 1990, which was crafted during the furor over steroids that arose after Canadian sprinter Ben Johnson tested positive for an anabolic steroid at the 1988 Summer Games in Seoul after winning a gold medal in the 100 meters.
Congress last year banned dozens of dietary supplements in an attempt to curb the distribution of steroid products. That law, which went into effect in January, was aimed primarily at products known as steroid precursors, substances that metabolize into illegal steroids only after they are ingested. The products obtained by The Post are full-blown steroids, Catlin said.
"Congress has spoken definitively, absolutely, on any kind of anabolic steroids or precursors," said Rep. John E. Sweeney (R-N.Y.), who is sponsoring legislation that would make it more difficult to buy banned steroids over the Internet by forcing Internet auction sites to more aggressively police themselves. "This is absolutely contrary to what we've already been very clear about. . . . It's really a flouting of the laws in place, and it requires Congress to look harder and close those loopholes."
It is against the law to sell drugs that are improperly labeled or not approved by the Food and Drug Administration.
Catlin's analyses of the five products obtained by The Post suggest that none is properly labeled as a dietary supplement, as defined in the Dietary Supplement Health and Education Act of 1994, which governs the industry and places dietary supplements in a special category under the general umbrella of foods rather than drugs. The FDA declared THG illegal after it was identified by Catlin in 2003, noting that it was a synthetic anabolic steroid.
FDA officials declined interview requests, according to FDA spokeswoman Kimberly Rawlings, but in an e-mailed statement she said the agency has been aggressively combating the distribution of steroids and steroid-like substances in dietary supplements. Rawlings cited regulatory steps taken since 2004 to remove androstenedione -- which is known as andro and was made famous by former baseball player Mark McGwire in the 1990s -- from the market.
"The agency is prepared to take appropriate action against any product that purports to be a 'dietary supplement' if it is determined that product contains steroids, steroid precursors or active ingredients found in prescription drugs," Rawlings said.
One of the steroids Catlin identified had been available on the underground steroid market before it made its way into supplements. In Ergomax LMG, Catlin said he found the steroid madol -- also known as DMT -- that attracted headlines after it was seized by Canadian customs in December 2003 from a former Canadian sprinter, who was prosecuted in Canada on drug charges earlier this year. After the athlete was caught with the drug, WADA declared it banned.
Bottles of Superdrol and Ergomax LMG obtained by The Post in August did not contain their chemical formulations on their labels, referring to their contents only by trademarked names -- Methasteron in the case of Superdrol and Pherobolix in the case of Ergomax. Catlin said neither name had any scientific meaning that would aid in identifying it.
A bottle of Prostanozol reported its chemical formulation, but used outdated chemical language in what Catlin said appeared to be an attempt to avoid being "flagged by some nasty government computer."
And two ingredients -- one a synthetic anabolic steroid, another a progestin, a close relative to a steroid -- did not match the chemical names reported on a bottle of Methyl 1-P, Catlin said.
An advertisement for FiniGenX Magnum on the company Web site gives insight into PharmaGenX's operating philosophy. "THE MOST POTENT DIETARY SUPPLEMENT EVER DEVELOPED FOR SIZE AND STRENGTH IS STILL LEGAL!" the advertisement says.
"Finigenx Magnum . . . was not on the updated Anabolic Steroid Control Act of 2004. We had independent chemists search the 'Act'" from top to bottom for Finigenx Magnum or any ingredients that are in our solution and they came up with ZERO, ZIP, NADA."
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DMT is wijdverbreid
Lezers van Ergogenics maakten ons er op attent dat er nog meer supplementen zijn die het designer-anabool
Maar exact diezelfde stof zit in Phera-Plex, gefabriceerd door de makers van Ergomax-LMG. De actieve stof in Phera-Plex is 17a-methyl-etioallocholan-2-ene-17b-ol, aldus de advertenties.
Etioallocholan is een verouderde term voor ‘androstan’, aldus door ons geraadpleegde experts. “Je komt hem nauwelijks tegen. Waarom je hem tegenkomt op commerciële preparaten? Waarschijnlijk omdat anabolen nu eenmaal een slechte reputatie genieten.”
Hoe dan ook, 17a-methyl-etioallocholan-2-ene-17b-ol is hetzelfde als 17alpha-methyl-5alpha-androst-2-en-17beta-ol. En dat is - tattaa! - gewoon Madol of DMT.
A Naturally Occurring Pheromone With Huge Anabolic Properties!, kwetteren de bodybuildingsites.
Dezelfde stof zit ook in Methyl-Plex XT™. Als je 17a-methyl-etioallocholan-2-ene-17b-ol intikt in Google zul je er wel nog wel meer vinden. Of anders tik je die andere fantasienaam in: 17-methyl-delta-2-etioallocholane. Altijd prijs.
Toen Pat Arnold een paar weken geleden de politie op visite kreeg, maakte hij daarna op de board van Bodybuilding.com grapjes. Hij leek zich niet zoveel zorgen te maken, ook al was het duidelijk dat de Amerikaanse overheid jaagt op de leveranciers van Balco. De verantwoordelijken voor de creatie van THG en DMT gaan voor de bijl, dat staat vast.
Arnold adviseerde iedereen zijn cafeďneknaller ErgoLean maar vast te gaan hamsteren. Dat zou nou wel snel van de markt af gaan.
We beginnen hem nu pas te snappen.
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Davis Gives FDA Deadline for Steroid Explanation
In the latest move by Congress to address the problem of steroids in sports, Rep. Thomas M. Davis III (R-Va.), chairman of the Government Reform Committee, gave the Food and Drug Administration a Nov. 7 deadline to explain what it is doing to ensure that dietary supplements do not contain anabolic steroids.
In a letter sent Friday to FDA Acting Commissioner Andrew C. von Eschenbach, Davis requested information regarding the FDA's oversight and monitoring of the dietary supplement industry and its plans to review five dietary supplements that contain steroids, as reported in an Oct. 18 Washington Post story.
"While the FDA does not approve dietary supplements for safety and effectiveness, FDA still has the responsibility to ensure that manufacturers do not mislead the consumer about dietary supplement contents," Davis wrote in the letter. "With the five dietary supplements tested in the previously mentioned Washington Post article, consumers could not know that they contained anabolic steroids."
Don Catlin, of the UCLA Olympic Analytical Laboratory in Los Angeles, analyzed the five products -- Applied Lifescience Research Industries' (ALRI) Ergomax LMG, Anabolic Xtreme's Superdrol, ALRI's Prostanozol, PharmGenX FiniGenX Magnum Liquid, and Legal Gear's Methyl 1-P -- for The Post and concluded that all contained anabolic steroids that were designed to avoid detection in current drug tests. The Post reimbursed Catlin for the cost of the testing.
The World Anti-Doping Agency recently announced that it would add steroids in three of the products -- all of which have been readily available online for between $50-$125 per bottle -- to its 2006 banned list.
The FDA could not immediately be reached for comment.
This February, the Committee on Government Reform began to investigate the use of illegal performance-enhancing drugs in professional sports, holding hearings on steroid use and the testing policies for professional baseball, football, and basketball, as well as the use of steroids among women.
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Open Letter To Washington Post and Ms. Amy Shipley
Author L. Rea
Dear Ms. Amy Shipley and AM Board Members,
Yesterday, a reporter from the Washington Post named Amy Shipley called looking for both of us to conduct interviews under the guise that she was looking for information about "new prohormones" since the last legislation was made into law. For obvious reasons it appears she was deliberately sent in our direction and to this very board/subsection of this board by another prominent person in the industry.
Sadly at times he acts in a myopic and petty manner. Unfortunately he seems to fully grasp that by doing what he did, he hurts not just us but the entire supplement industry, once again.
Both of us have declined to give Ms. Shipley (who will surely be reading this) a private, exclusive interview in person or on the telephone because the media has a history of selectively editing quotes to make a story fit the way they want to (this used to be called yellow journalism by the way and these types of articles belong on the Editorial or Op Ed pages of a newspaper, not presented as unbiased, objective news). We would like to believe that perhaps this is different.
Nonetheless, we both have decided to make a public statement/press release here on this board before Ms. Shipley writes her article for the Washington Post.
Both of us have not, are not and will not violate any laws at the federal, state or local level regarding the sale of controlled substances. It simply is unnecessary and not conducive to our goals of providing safe and health oriented products for the betterment of all whom opt to be at their best.
None of the compounds we have developed and currently market are in current violation of any controlled substance act at either the federal or state level. None of the compounds we are developing together or alone violate any of the controlled substance acts at either the federal or state level as they currently are written and enacted into law. Naturally we sought out the best legal council to validate our research.
Both of us believe strongly in freedom of choice you as an adult have a right to make an educated and intelligent choice as to what you personally want to put into your body without interference or judgement passed down on you by others so long as what you are putting into your body does not violate any law.
The very few select products we make that are of a controversial nature have very stern and unambiguous warnings printed clearly on the label. Our labels clearly read that one should consult with their health care provider/physician BEFORE using the product. Our labels clearly read that these products should not be used by people under the age of 18/21, by women or by people with renal, hepatic, cardiovascular or psychiatric diseases. Furthermore, our labels clearly read that users of these supplements should only use them for very brief periods of time.
It is our policy to STRONGLY dissuade the use of these products by people who are not of legal age. Consequently, we do not advertise in ANY media of any sort focused towards teenagers or children.
Additionally, we do not condone the use of any of these products by professional or amateur athletes looking to circumvent testing for banned substances whether the testing is conducted by the WADA, USADA, AAU, NCAA., etc.
We feel that our products are correctly (and legally) marketed to and for educated, intelligent adult men between the ages of 18/21 to 60+ who want to look better, feel better and perform better. We do not, will not and have not marketed these few products to or for people not of legal age, women or people who participate in any type of organized sporting events be they professional or amateur.
If Ms. Shipley genuinely wishes to discuss the state of prohormones with us after the passing of the recent legislation in an objective, unbiased manner, we would be happy to entertain her questions AT OUR DISCRETION, here in this public forum. This way, there can be no misunderstandings or accidental misquotes attributed to any party. We only request that Ms. Shipley come out and admit she is reading this subsection of this board and post her questions openly, under her own name.
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Effective immediately, Applied Lifescience Research Industries, Inc., has ceased production, marketing and sale of all Ergomax LMG, Prostanozol and similar products.
We are proud of the products that we have developed and marketed to help our customers achieve their training and fitness goals.
However, while it was never our objective to create or market supplement products for the purposes of undetectability in doping tests or to undermine fairness in sports in any way, we have decided that the most appropriate course of action is to discontinue these products at this time, and to focus instead on continuing to bring you innovative new quality supplements.
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New ALRI innovations in the hopper
Thought you guys would find this post from AM interesting. Here's a link to the thread: http://anabolicminds.com/forum/archives-alri/30969. [Geblokkeerd]
Just as a heads up for folks, Author [Author L Rea - red.] and I [Bruce Kneller - red.] are working with a very talented guy in China now who has two doctoral degrees (one from Peking University which is about the best university in China and one from a university in Ireland), a PhD in Analytical Chemistry and a DSc in Organic Chemical Synthesis.
The guy is TOP NOTCH and is hands down, the best synthetic chemist available to the sports nutrition industry in all of China...
Scratch that, this guy can make anything, he is the best synthetic chemist available to our community IN THE WORLD (including the USA).
He's tip top, teaches chemistry at the graduate level in China and is an exclusive consultant to Author and myself. He did not come cheap - we have him on retainer now to work with us and us alone. So it is unlikely other companies are going to be able to come up with the cool chemicals ALRI and Gaspari are going to have access to at the purity and price levels we will have.
I spoke with Author at length last night and we have decided that we really want to have "Chemist X" focus his efforts for us on the C4, -OH modified compounds. You might remember such cool C4, -OH modifieds compounds like MOHN, OHN, Formestane, etc.?!?
Well, we're going to take this a step further. The hydroxyl at C4 makes otherwise aromatizable steroids unaromatizable (usually) and also gives the compound (usually) some inherent anti-aromatic qualities itself.
Author is having our 'friend in Chengdu' make small (a few grams) of the following goodies for us to play with -
4,17b-diydroxyestra-4,9,11-trien-3-one (did someone ask for 'trenbolone'?)
17a-methyl-4-hydroxy-4,9-dien-3-one (this one should be VERY cool)
4-hydroxy-1-methyl-5alpha-androst-1-en-3-one (probably as a 17b ester - think "legal Primobolan")
4-hydroxy-17a-methyl-2-oxa-5a-androstane-3-one (the Anavar variant)
and of course, what stack would be complete without dbol?: 4-hydroxy-17a-methyl-androsta-1,4-dien-3-one (no bloat, non-aromatizing)
Now we are 'alpha testing' these goodies in August and no, we don't need volunteers to 'assist us' (sorry guys, you will need to wait until we either beta test or we just launch the products).
I do want to know, and Author surely does too, which of these would be your TOP TWO choices since we can't launch them all, I discussed this with Author and he's going to set up a poll here so you guys can help us decide, what gets made and what gets the proverbial boot. Your input is important.
Now these will not be inexpensive, figure on the best price to you guys for this stuff is going to end up at $50 a bottle for like a months supply but they are all NOT ILLEGAL at this point and would really kick ass as "proto-steroids" for as long as we can sell them for.
We're also working on a few THP and undecanoate ester products for those of you who are "uninclined to use C-17a alkylated products" like most of the ones I just wrote about.
I am pretty sure the 4-OH trenbolone analog will end up being made as a THP ether in a gel cap (with oleic acid) at 25mg per pop (you'd need 2-4 per day). But hey, it is essentially oral, legal Parabolan so I mean, how cool is that?
We're also likely to do a 4-OH DHT 17b-THP ether too in a gel cap as a "low buck" non-methyl.
I am really excited to be working with the folks at ALRI/Author on these products. It just proves that good minds in the industry and "rival companies" do not have to act disrespectfully towards each other and try to sabotage each others ideas. It's been a pleasure, really it has, talking with Author and I look forward to working with him more and more in the future.
You see, when creative minds come together, usually cool idea come out of the conversations and you guys end up with really good, effective products, better choices and this is good for the industry.
Gaspari Orastan-E and ALRI Prostanozol were the first project(s) we successfully did together and I bet you're going to see plenty more in the future.
I really think, and I know Author concurs or we would obviously not be working together, that it's better to have a friend than an enemy and it is better to work as a team than by yourself.
Anyhow, we want to know what you guys all think of all this in general and the compounds we propose.
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Ze praten elkaar weer na
Experts hebben op de boards de post van Kneller uitvoerig bediscussieerd. Nu de zoekmachines die discussies in kaart hebben gebracht, is het internet ineens een stel exotische zoektermen rijker.
Kneller heeft in de haast een paar tikfoutjes gemaakt. Zo spreekt hij van de verknutselde trenbolone per abuis van 4,17b-diydroxyestra-4,9,11-trien-3-one.
Het had moeten zijn 4,17b-dihydroxyestra-4,9,11-trien-3-one. Kneller is een H vergeten. Kan gebeuren.
Een ander tikfoutje staat in 17a-methyl-4-hydroxy-4,9-dien-3-one, het tweede anabool dat Kneller noemt. Dat moet zijn: 17a-methyl-4-hydroxy-estra-4,9-dien-3-one. En weer krijg je wel hits op Google als je de foute naam intikt, maar helemaal niks als je het met de correcte terminologie probeert.
De vraag die onwillekeurig bij je opkomt: zijn de heren te lui om een tikfout te corrigeren? Of zien ze het gewoon niet?
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Wat zit er in Halodrol?
Op het doosje staat Polydehydrogenated Polyhydroxylated Halomethetioallocholane. Maar wat is dat?
Pat Arnold gokt op 1-dehydrofluoxymesterone: de 1-testosteronvariant van halotestin. Hieronder zie je eerst de structuurvergelijking van halotestin, en daaronder hoe de 1-testosteronvariant eruit zou kunnen zien.
Hieronder zie je een andere mogelijkheid. Onze eigen speculatie, zeg maar.
Wat er ook in Halodrol zit, het zou wel eens een knap riskant goedje kunnen zijn, vreest het board. Arnold verzoekt iemand hem wat pillen op te sturen, zodat hij ze kan onderzoeken.
Een bezoeker mailt een link door met een patent op FreshPatents.com. Die gaat over androgenic 7-substituted 11-halogen steroids. Heeft dat daar iets mee te maken?
In dezelfde draad komt Methoxy-TRN ter sprake. Nog een product van ALRI. Het gaat om trenbolone met een methoxylgroep aan 17beta, verklapt Bruce Kneller.
17b-methoxy-trenbolone werkt niet, vermoedt Arnold.
"I don't believe that this compound will have any activity", schrijft hij. "It would have to be metabolized back into the 17beta-hydroxyl compound." En de enzymen die die je daarvoor nodig hebt vind je niet in het menselijk lichaam, vreest Arnold.
This Is What Is In Halodrol-50
Rich gave me the 'green light' to reveal what is in it. Do your own research after this.
Halodrol 50 = 4-chlorodehydromethylandrost-4-ene-3,17b-diol; 50mg per tablet.
Happy now? It's a derivative of Oral Turinabol (the 3 hydroxyl variant).
It is halogenated like the box reads (4-chloro). It is dehydrogenated (DB's at 1 and 4). It is polyhydroxylated (hydroxyls at 3 and 17b) It is methylated (C17a).
It's effects are very similar and it's side effects very similar to Oral Turinabol.
I clipped this off the net about OT (it is a good comparator to what you can expect from H-50l I did not write this but I did edit some of it).
Oral-Turinabol is an oral steroid which was developed during the early 1960's. OT has a predominantly anabolic effect which is combined with a relatively low androgenic component. On a scale of 1 to 100 the androgenic effect is very low -only a 6- and the anabolic effect is 53. (In comparison: the androgenic effect of Dianabol is 45 and its anabolic effect is 90.)
Oral-Turinabol thus has milligram for milligram a lower effect than Dianabol. It is therefore not a steroid that causes a rapid gain in strength, weight, and muscle mass. Rather, the achievable results manifest themselves in a solid muscle gain and, if taken over several weeks, also in a good strength gain. The athlete will certainly not get a puffy look as is the case with Testosterone, Dianabol, and Anadrol 50. The maximum blood concentration of Oral-Turinabol when taking 10, 20 or 40 mg/day is 1.5 -3.5 or 4.5 times the endogenous testosterone concentration (also see Dianabol). This clearly shows that the effectiveness of this compound strongly depends on the dosage.
An athlete weighing 200 pounds would take only 4 tablets of 5 mg (20mg/day.) In our experience bodybuilders take 8-10 tablets of 5 mg, that is 40-50 mg/day. Many enthusiastically report good results with this dosage: one builds a solid muscle mass, the strength gain is worthwhile seeing, the water retention is very low, and the estrogen-caused side effects are rare. Not without good reason OT is also popular among powerlifters and weightlifters who appreciate these characteristics.
Due to its characteristics OT is also a suitable steroid both for men and women in competitions. A usually very effective stack for male bodybuilders consists of 50 mg OT/day, 228 mg Parabolan/week, and 150 mg Winstrol Depot/week.
Those who have brought their body fat content to a low level by dieting and/or by using fatburning substances (e.g. Clenbuterol, Ephedrine, Salbutamol, Cytomel, Triacana), will find that the above steroid combination will manifest itself in hard, sharply-defined but still dense and full muscles. No enlarged breasts, no estrogen surplus, and no watery, puffy-looking muscle system. If OT were available on the U.S. black market for steroids, bodybuilders, powerlifters, and weightlifters would go crazy for this East German anabolic.
OT enjoys a great popularity since it is quickly broken down by the body and the metabolites are excreted relatively quickly through the urine. The often-posed question regarding how many days before a test OT can be taken in order to be "clean" is difficult to answer specifically or in general. We know from a reliable source that athletes who only take OT as a steroid and who, in part, take dosages of 10- 15 tablets/day, have discontinued the com-pound exactly five days before a doping test and tested negative. These indications are supported by the fact that even positive urine analyses have rarely mentioned the names Oral-Turinabol or chlordehydromethyltestosterone.
The potential side effects of OT usually depend on the dosage level and are gender-specific. In women, depending on their predisposition, the usual virilization symptoms occur and increase when dosages of more than 20 mg per day are taken over a prolonged time.
In men the already discussed reduced testosterone production can rarely be avoided. Gynaecomastia occurs rarely with OT Since the response of the water and electrolyte household is not overly distinct athletes only rarely report water retention and high blood pressure. Acne, gastrointestinal pain, and uncontrolled aggressive behavior are also the exception rather than the rule with OT.
An increased libido is reported in most cases by both sexes. Since the substance chlordehydromethyltestosterone is 17-alpha alkylated the manufacturer in its package insert recommends that the liver function be checked regularly since it can be negatively affected by high dosages and the risk of possible liver damage cannot be excluded. Thus OT is also a steroid that can be taken without interruption for long intervals. Studies of male athletes who over a period of six weeks were given 10 mg OT/day did not show any indications of health-threatening effects.
There you have it. Remember, 1-AD was a 3,17b diol and it worked well. So did 4-AD and Methyl-4AD. H-50 is a good, clean, effective compound.
I am done posting, this has given me a headache.
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Congress Unhappy With FDA
Davis Labels Investigation of Steroids Makers as Inadequate
By Amy Shipley
The Food and Drug Administration is investigating five dietary supplements recently found to contain steroids and is considering enforcement action against the companies that produced them, the agency said in a letter delivered Monday to House Government Reform Committee Chairman Thomas M. Davis III (R-Va.). Davis yesterday described the FDA response as inadequate.
The letter said an FDA investigative team is seeking evidence from Don Catlin, the director of the UCLA Olympic Analytical Laboratory in Los Angeles who evaluated the supplements for The Washington Post, which published the findings in an Oct. 18 story. Before the story ran, all of the products were available over the Internet, costing between $50 and $125 per bottle. Catlin said each of the products contained newly created steroids designed to elude detection in standard sport drug screens.
Davis, who requested soon after the story's appearance that the FDA explain its efforts to ensure that steroids are not found in dietary supplements, yesterday demanded more specific information on the investigative effort. In his Oct. 21 letter, Davis asked for details on how the FDA was dealing with the companies mentioned in The Post article and other issues, but the FDA provided mostly general information about how it oversees the industry in its five-page response and 48-page attachment.
"While I appreciate the FDA's compliance to our deadline, I would prefer a late but substantive response as opposed to an inadequate prompt one," Davis said in a statement. "Given the disturbing trend of teenage steroid-use and the apparent increase in designer steroids production, FDA must provide specific answers to help us turn back this rising tide."
The steroids discovered in the dietary supplements also have attracted the attention of the Drug Enforcement Agency, which has turned chemical information about the steroids over to its pharmacologists to determine whether each should be banned, according to Rogene Waite, a DEA spokeswoman. The process could take months. For drugs such as steroids, the DEA does not have the authority to issue emergency bans, Waite said. It must undergo a laborious process that includes publishing its intent to schedule in the Federal Register and allowing for time for comment and review.
Several companies have voluntarily removed products from the market since The Post story appeared, which the FDA noted in its letter. Applied Lifescience Research Industries (ALRI) announced two weeks ago it had discontinued sales of two products mentioned -- Prostanozol and Ergomax LMG -- and all similar products.
Anabolic Xtreme discontinued sales of three of the products mentioned (two licensed from ALRI) and Serious Nutrition Solutions announced on its Web site that it was withdrawing two of its dietary supplements -- neither of which was mentioned in the story -- "since finding out about legal issues surrounding these products after the initial first small product run."
(Serious Nutrition Solutions haalde Methyl-Plex XT en Methyl-Drol XT uit de schappen. Daar zat respectievelijk DMT en superdrol in. Anabolic Xtreme stopte met de verkoop van Phera-Plex (DMT), Superdrol en Prostanozol. Verder ziet het ernaar uit dat ALRI ook 17b-methoxy-trenbolone uit het assortiment heeft gehaald - red.)
"We know that there are several superior supplemental health and performance promoting options for athletes and enthusiasts alike, and that hormone related compounds just seem like a step backwards," said ALRI director Author L. Rea in an e-mail. "The FDA has been very supportive in furthering the types of products that do not call into question an athlete's or company's ethics, that ALRI is focusing solely on providing proof it can be done very well."
Several companies, however, have released dietary supplements that appear to contain steroids in the last few weeks, according to information available about the products, industry sources and chemistry experts.
The FDA "shares your concern about the use of steroids among adolescents and the apparent increase in so-called designer steroid production and use," said Patrick Ronan, FDA Associate Commissioner for Legislation, in Monday's letter to Davis. "We will consider enforcement and other options as part of the agency's investigation of this matter once this evidence has been evaluated."
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Steroids Detected In Dietary Tablets
Some Contents Similar To Those Used by East German Athletes
By Amy Shipley
A dietary supplement marketed to fitness and health enthusiasts on the Internet and in body-building shops contains anabolic steroids linked to two of the biggest doping scandals in sports history, including the renowned case involving East German Olympic athletes in the 1960s and '70s, according to a prominent researcher.
The supplement, which is sold under the name Halodrol, contains a steroid that closely resembles Oral-Turinabol, the principal steroid used to fuel East Germany's secret, systematic sports doping program, according to Don Catlin of the UCLA Olympic Analytical Laboratory.
Catlin said it also contains DMT, or madol, a steroid federal authorities say was developed for Bay Area Laboratory Co-operative (BALCO), the California nutritional supplement company at the center of a scheme to provide prominent professional athletes with undetectable performance-enhancing drugs.
Catlin analyzed the makeup of Halodrol-50 for The Washington Post, which purchased the product on the Internet and reimbursed the Los Angeles researcher for the cost of the testing.
The discovery provides further evidence that the country's multimillion-dollar dietary supplements industry also has become a clearinghouse for the distribution of anabolic steroids, which help build muscle and speed recovery from strenuous exercise but also can cause serious health problems when used in excess.
Last month, Catlin tested five other dietary supplements obtained by The Post and found that each contained anabolic steroids, four of which had not been previously detected. The Food and Drug Administration announced after publication of The Post's story on Oct. 18 that it had opened an investigation into the four companies marketing them.
An FDA spokeswoman said yesterday that the investigation is continuing. The official declined further comment.
It is illegal to sell anabolic steroids or any unapproved drugs as dietary supplements.
Halodrol-50, which costs $50 to $80 for a bottle of 30 tablets, is marketed by Gaspari Nutrition, a dietary supplements company based in Neptune, N.J., that sells bodybuilding and weight-loss products. Halodrol-50 claims on its label to "induce maximal visible changes in size and strength in the shortest period of time possible." It also recommends that the product not be used by anyone under age 21.
The Halodrol-50 label further states that it contains polydehydrogenated, polyhydroxylated halomethetioallocholane. Catlin described that chemical descriptor as "hocus-pocus." He said the language was outdated and vague and appeared to be deliberately misleading. The label makes no mention of DMT or other anabolic steroids.
"It's obfuscation," [beneveling, verwarring - red.] Catlin said. "There is no attempt to be clear and concise and to describe the product for what it is."
Rich Gaspari, owner of Gaspari Nutrition, did not respond to two requests for an interview made by telephone to associates at his company. He also did not respond to two e-mail requests for comment.
However, Bruce Kneller, a consultant to Gaspari, wrote in an e-mail late yesterday that he had spoken to Gaspari and was conveying a comment on Gaspari's behalf. "The product . . . was discontinued several weeks ago after the publication of an inflammatory article in The Washington Post," Kneller said, referring to the Oct. 18 Post story. "It is no longer made or sold by Gaspari Nutrition and, in fact, was only available for less than three weeks."
In an e-mail sent by a Gaspari official to a distributor, which was provided to The Post, the Gaspari official said Halodrol-50 and another product called Orastan E [prostanozol - red] no longer advertised on Gaspari's Web site would continue to be sold to good customers. The Gaspari official added that he hoped "the government and media will ignore us and think we got rid of them," focusing instead on the "other companies."
Oral-Turinabol anchored the secretive doping program in communist East Germany that led to that country's emergence as an Olympic power three decades ago, according to classified documents uncovered in 1990 following the fall of the Berlin Wall. At the 1976 Summer Games in Montreal, East German women won 11 of the 13 swimming events. But the side effects from the massive doses of steroids administered to the East German competitors were as remarkable as the athletes' successes. Women developed excessive body hair, deepened voices, massive shoulders and male secondary sex characteristics.
Criminal trials in 2000 resulted in the convictions of East Germany's Olympic president and chief sports doctor, but a number of former athletes are still grappling with medical, legal and psychological issues related to the doping program.
One of the two steroids found in Halodrol-50, Catlin said, more closely resembles Oral-Turinabol than any other known steroid, but the two are not identical in structure. The steroid would be undetectable in standard drug tests because it is not an exact match with Oral-Turinabol.
"This is an unknown," Catlin said. "If I had to pick one it's ever so close to, it's Oral-Turinabol. . . . It's very close."
Athletes taking Halodrol-50 would flunk standard sport drug tests, however, because DMT -- which Catlin identified more than a year ago -- is now detectable. DMT was one of three steroids found associated with BALCO. The others were norbolethone and THG, also known as "the clear."
The FDA is investigating four other dietary supplement companies named in the Oct. 18 story in which The Post reported that Catlin had found anabolic steroids in five products produced by four companies: Anabolic Xtreme, Applied Lifescience Research Industries, Legal Gear and PharmaGenX. The story led Rep. Thomas M. Davis III (R-Va.) to demand that the FDA explain its efforts to ensure that dietary supplements did not contain steroids. The FDA said in a Nov. 7 letter to Davis that the companies could face punitive action.